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KMID : 0043319940170060480
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Archives of Pharmacal Research
1994 Volume.17 No. 6 p.480 ~ p.482
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5-Substituted Pyrimidine Acyclis Nucleoside Analogues 1-Cyanomethyl- and 1-(4-Cyanobutyl)-5-substituted Uracils as Candidate Antitumor Agents
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Kim Jack-C.
Dong Eun-Soo
Park Jin-Il
Bae Sang-Duk
Kim Seon-Hee
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Abstract
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A number of 5-substituted pyrimidine acyclic nucleosides were synthesized and tested for invitor cytotoxicity against four cell lines (j-82 cell, p-388 cell, FM-3A cell and U-938 cell lines). Synthesis of 1-cyanomethyl-5-substituted pyrimidines (1a-e) and 1-(4-cyanobutyl)-5-substituted pyrimidines (2a-e) was acomplished from the series of alkylation reactions ofl 5-substituted uracils with the corresponding chloacetonitrile and 5-chlorovaleronitile in DMSO under temperature. These 5-substituted pyrimidine acylic nucleosides (1a-e and 2a-e) exhibited moderate to significant acitivity aginst four cell lines.
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KEYWORD
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Acyclic nucleoside analogues, 1-Cyanomethyl -5substitued pyrmidines, 1-(4-Cya-nobutyl)-5-substituted pyrimidines, Antitumor activity, Human bladder carcinoma cell(J-82), Mouse mammary carcinoma(FM03A), Mouse lymphoid neoplasma(P-388), Human histiocytic lymphoma(U-937)
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